non prescription cialis online pharmacy In another embodiment, the present invention provides a method of treating a solid tumor comprising administering to a patient in need thereof a compound of formula I and one or more additional therapeutic agents selected from rituximab Rituxan, cyclophosphamide Cytoxan, doxorubicin Hydrodaunorubicin, vincristine Oncovin, prednisone, a hedgehog signaling inhibitor, a BTK inhibitor, a JAK pan JAK inhibitor, a TYK2 inhibitor, a PI3K inhibitor, a SYK inhibitor, and combinations thereof